منابع مشابه
Charge movement in the sodium channel
Patlak (1995) present a new estimate of the charge displacement that occurs in the activation of voltage-gated sodium channels. This kind of estimate is not new-Hodgkin and Huxley (1952) pointed out that the movement of at least six elementary charges (e0) must somehow accompany the activation of the sodium conductance. The surprise from the new result of Hirschberg et al. (1995) is that the es...
متن کاملTotal Charge Movement per Channel
One measure of the voltage dependence of ion channel conductance is the amount of gating charge that moves during activation and vice versa. The limiting slope method, introduced by Almers (Almers, W. 1978. Rev. Physiol. Biochem. Pharmacol. 82:96-190), exploits the relationship of charge movement and voltage sensitivity, yielding a lower limit to the range of single channel gating charge displa...
متن کاملStructural basis for gating charge movement in the voltage sensor of a sodium channel.
Voltage-dependent gating of ion channels is essential for electrical signaling in excitable cells, but the structural basis for voltage sensor function is unknown. We constructed high-resolution structural models of resting, intermediate, and activated states of the voltage-sensing domain of the bacterial sodium channel NaChBac using the Rosetta modeling method, crystal structures of related ch...
متن کاملGating of the Bacterial Sodium Channel, NaChBac: Voltage-dependent Charge Movement and Gating Currents
The bacterial sodium channel, NaChBac, from Bacillus halodurans provides an excellent model to study structure–function relationships of voltage-gated ion channels. It can be expressed in mammalian cells for functional studies as well as in bacterial cultures as starting material for protein purification for fine biochemical and biophysical studies. Macroscopic functional properties of NaChBac ...
متن کاملMolecular Basis of Charge Movement in Voltage-Gated Sodium Channels
Voltage-dependent movement of a sodium channel S4 segment was examined by cysteine scanning mutagenesis and testing accessibility of the residues to hydrophilic cysteine-modifying reagents. These experiments indicate that 2 charged S4 residues move completely from an internally accessible to an externally accessible location in response to depolarization by passage through a short "channel" in ...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1995
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.106.6.1047